Our broad pipeline includes five proprietary agents with differentiated mechanisms of action. Those in the most advanced stages of development are in the clinic to fight cancer, immune disorders, and infectious diseases
CPI-818 is an oral, small molecular drug that selectively inhibits ITK (interleukin-2-inducible T cell kinase), an enzyme expressed predominantly in T cells and that plays a role in T cell and natural killer (NK) cell lymphomas and leukemias, as well as in normal immune function. The optimal dose of CPI-818 has the potential to induce the activation, differentiation and expansion of T cells to TH1 helper cells while blocking the deployment of TH2 cells. Th1 T cells are required for immunity to tumors, viral infections and other infectious diseases. Th2 helper T cells are involved in the pathogenesis of many autoimmune and allergic diseases. We believe the inhibition of specific molecular targets in T cells may be of therapeutic benefit for patients with T cell lymphomas and leukemias and in patients with autoimmune and allergic diseases.
Corvus and its partner in China, Angel Pharmaceuticals are conducting a Phase 1/1b trial in patients with refractory T-cell lymphomas that was designed to select the optimal dose of CPI-818 and evaluate its safety, pharmacokinetics, target occupancy, immunologic effects, biomarkers and efficacy. Interim data from the Phase 1/1b clinical trial of CPI-818 for T cell lymphoma demonstrated tumor responses in very advanced, refractory, difficult to treat T cell malignancies, and identified a dose that maximally affects T helper cell differentiation. Corvus is planning to conduct clinical studies with CPI-818 in autoimmune diseases and allergies.
Corvus is a leader in the development of precisely targeted therapies targeting the adenosine pathway. Ciforadenant is a small molecule antagonist of the adenosine A2A receptor, a key step in the adenosine pathway leading to immunosuppression in the tumor microenvironment. By precisely targeting and blocking A2A receptors on immune cells, ciforadenant may unleash their cancer-killing properties.
Results from a Phase 1/1b clinical trial demonstrated that ciforadenant was active alone and in combination with atezolizumab in patients with advanced, refractory renal cell cancer (Fong et al., Cancer Discovery 2020). The study also describes the Adenosine Gene Signature, a novel biomarker, which was found to be beneficial in identifying patients most likely to respond to therapy.
An open-label Phase 2 trial of ciforadenant in first line therapy for metastatic renal cell cancer in combination with ipilimumab (anti-CTLA-4) and nivolumab (anti-PD-1) is planned to be conducted in collaboration with the Kidney Cancer Clinical Trials Consortium. The trial design is based on Corvus’ preclinical research published in 2018 in Cancer Immunology Research that demonstrated impressive antitumor control and cures in several animal models using ciforadenant in combination with anti-CTLA-4 and anti-PD1.
Corvus has designed a randomized Phase 2 clinical trial evaluating mupadolimab as front-line therapy for the treatment of patients with advanced NSCLC. The randomized, blinded trial is designed to compare standard chemotherapy plus pembrolizumab (anti-PDL-1) with or without mupadolimab in patients with any tumor PDL-1 expression. The primary endpoint for the trial is progression-free survival. With a current focus on CPI-818, the Company does not plan to initiate this trial in 2022. Angel Pharmaceuticals plans to continue the development of mupadolimab in China and will start a Phase 1 trial in lung cancer and in head and neck cancers in late 2022.
For more information on our pipeline, please see our Annual Report available in the SEC Filings section of the website.
We are developing immunology focused medicines that target the most critical elements of the tumor immunity axis
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