Activating the Immune System to Fight COVID-19

CPI-006 is an immunomodulatory antibody that binds to immune cells, leading to activation of B cells and antibody production that we believe will destroy the SARS-CoV-2 virus.

This therapy has the potential to be used in mild or moderately ill COVID-19 patients as well as in healthy people to enhance the efficacy of vaccines.

Increasing the immune response to the COVID-19 infection may lead to faster viral clearance, shorter recovery time, less complications and longer lasting immunity

This approach has the potential to be a foundational therapy for SARS-CoV-2 mutant variants, other coronaviruses or future pandemics

 

COVID-19 Publications and Presentations

Presentations


Immunotherapy with B cell activating antibody CPI-006 in patients with mild to moderate COVID-19 stimulates anti-SARS-CoV-2 antibody response, memory B cells, and memory T effector cells

Gerard Criner, M.D., Chair & Professor, Thoracic Medicine & Surgery, Lewis Katz School of Medicine at Temple University

Oral presentation at the 2020 Society for Immunotherapy of Cancer (SITC) 35th Annual Meeting


Immunotherapy with B cell activating antibody CPI-006 in patients with mild to moderate COVID-19 stimulates anti-SARS-CoV-2 antibody response, memory B cells, and memory T effector cells

Criner G1, Mobasher M2, Hill C2, Hu S2, Mahabhashyam S2, Brody J3, Marron T3, Willingham S2, Miller R2 

1Temple University Hospital, Philadelphia, PA, USA; 2Corvus Pharmaceuticals Inc, Burlingame, CA, USA; 3Icahn School of Medicine at Mount Sinai, New York, NY, USA 

Poster presentation at the 2020 Society for Immunotherapy of Cancer (SITC) 35th Annual Meeting

Publications


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Characterization and Phase 1 Trial of a B Cell Activating Anti-CD73 Antibody for the Immunotherapy of COVID-19

Stephen B. Willingham, Gerard Criner, Craig Hill, Shenshen Hu, Jenny A. Rudnick, Barbara Daine-Matsuoka, Jessica Hsieh, Haider Mashhedi, Andrew N. Hotson, Joshua Brody, Thomas Marron, Emily Piccione, Joseph J. Buggy, Suresh Mahabhashyam, William B. Jones, Mehrdad Mobasher, and Richard A. Miller

medRxiv doi: 10.1101/2020.09.10.20191486

Our Science

We are developing oncology medicines with differentiated mechanisms of action directed at precisely-defined molecular targets

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